The design and scalable construction of robust ultrathin protein membranes with tunable
separation properties remain a key challenge in chemistry and materials science. Here, we
report a macroscopic ultrathin protein membrane with the potential for scaled-up fabrication
and excellent separation efficiency. This membrane, which is formed by fast amyloid-like
lysozyme aggregation at air/water interface, has a controllable thickness that can be tuned to
30–250 nm and pores with a mean size that can be tailored from 1.8 to 3.2 nm by the protein
concentration. This membrane can retain > 3 nm molecules and particles while permitting the
transport of small molecules at a rate that is 1~4 orders of magnitude faster than the rate of
existing materials. This membrane further exhibits excellent hemodialysis performance,
especially for the removal of middle-molecular-weight uremic toxins, which is 5~6 times
higher in the clearance per unit area than the typical literature values reported to date.


Facui Yang,Fei Tao,Chen Li,Lingxiang Gao & Peng Yang.


Nature Communications,9:5443(2018)